Early-Onset Colorectal Cancer in Algeria: A Call for Tailored Management Based on Clinical and Molecular Insights

Conference

Salah Eddine El Herrag, Douniazad El Mehadji, Djamila Yekrou, Soraya Moulessehoul, Méghit Boumediène Khaled
4ᵗʰ national seminar of biology and health (SNBS), Djillali Liabes University, 2023 Oct 21

DOI: 10.17605/OSF.IO/5R4UC

Abstract 4ᵗʰ SNBS 2023

Cite

APA Click to copy
El Herrag, S. E., El Mehadji, D., Yekrou, D., Moulessehoul, S., & Khaled, M. B. (2023). Early-Onset Colorectal Cancer in Algeria: A Call for Tailored Management Based on Clinical and Molecular Insights. Djillali Liabes University. https://doi.org/10.17605/OSF.IO/5R4UC

Chicago/Turabian Click to copy
El Herrag, Salah Eddine, Douniazad El Mehadji, Djamila Yekrou, Soraya Moulessehoul, and Méghit Boumediène Khaled. “Early-Onset Colorectal Cancer in Algeria: A Call for Tailored Management Based on Clinical and Molecular Insights.” 4ᵗʰ national seminar of biology and health (SNBS). Djillali Liabes University, 2023.

MLA Click to copy
El Herrag, Salah Eddine, et al. Early-Onset Colorectal Cancer in Algeria: A Call for Tailored Management Based on Clinical and Molecular Insights. Djillali Liabes University, 2023, doi:10.17605/OSF.IO/5R4UC.

BibTeX Click to copy

@conference{el2023a,
  title = {Early-Onset Colorectal Cancer in Algeria: A Call for Tailored Management Based on Clinical and Molecular Insights},
  year = {2023},
  month = oct,
  day = {21},
  organization = {Djillali Liabes University},
  series = {4ᵗʰ national seminar of biology and health (SNBS)},
  doi = {10.17605/OSF.IO/5R4UC},
  author = {El Herrag, Salah Eddine and El Mehadji, Douniazad and Yekrou, Djamila and Moulessehoul, Soraya and Khaled, Méghit Boumediène},
  month_numeric = {10}
}

Abstract
Introduction
Colorectal cancer (CRC) is a major global health problem, with a growing incidence among younger people. Early-onset CRC (EOCRC) is defined as CRC diagnosed before the age of 50. This study investigated the clinical and molecular characteristics of EOCRC in Algeria to better understand this disease.
Methods
The study retrospectively analyzed data from 56 EOCRC patients treated at the Anti-Cancer Centre of Sidi Bel Abbes, Algeria, between 2018 and 2021.
Results
The patients had a near-even gender distribution (48% female, 52% male), which contrasts with the male-predominant pattern observed in older-onset CRC. Tumors were localized in the colon (46%) or rectum (54%). Notably, 33% of patients had a family history of cancer, suggesting a potential genetic component. KRAS mutations were detected in 56% of cases, which is higher than the reported prevalence in older-onset CRC. This finding warrants further investigation to assess the prognostic and therapeutic implications of KRAS mutations in EOCRC. Adenocarcinoma was the most common histological subtype (96%), with 57% of tumors being well-differentiated. Disease staging revealed that 29% of patients had stage III CRC and 29% had metastatic disease, including 18% with liver metastases. Treatment varied, with chemotherapy (48%), adjuvant chemotherapy (37%), radiotherapy (13%), and targeted therapy (17%) being administered. The most common symptoms reported by patients were asthenia (41%), pain (36%), and weight loss (24%).
Conclusion
This study provides valuable insights into the characteristics of EOCRC in Algeria. The findings highlight the need for tailored management of EOCRC due to its increasing incidence, aggressive clinical course, and high prevalence of KRAS mutations.

Poster: Early-Onset Colorectal Cancer in Algeria: A Call for Tailored Management Based on Clinical and Molecular Insights